Endocrine Abstracts

Objective: To learn characteristics of biochemical markers of bone metabolism, parameters of bone mineral density (BMD) and fat component of body composition for early diagnosis of bone disorders in children with primary nephrotic syndrome (NS).Material and methods: We compared data of laboratory investigations (phosphorus (P), total calcium (Ca), parathyroid hormone (PTH), and alkaline phosphatase (ALP)), protocols of dual-energy X-ray absorbtiometry of...

Background: The pathophysiological base of metabolic syndrome is insulin resistance. According to Scott E.M., Grant P.J., insulin resistance is supposed to be formed during the evolution and connected by circadian rhythms. Melatonin is synchronizer of circadian rhythms. The modern lifestyle leads to the breach of melatonin synthesis because of absence of season changes in the length of a light day due to the using of artificial lighting.Aim: The aim was ...

Objective: to assess the effects of associated autoimmune diseases on diabetes control, growth, lipid profile in children with type 1 diabetes mellitus (T1DM) and to determine the most predictive genetic, immune and metabolic risk factors of polyglandular autoimmunity in children with T1DM.Material and Methods: 89 children with combined autoimmune pathology (main group, age 11.82 ± 3.68 years) and 100 patients with isolated T1DM (control group, age ...

ObjectiveTo determine predictive factors of co-existing autoimmunity in children with type 1 diabetes mellitus (T1D).Material and methods64 children with combined autoimmune pathology (T1D and autoimmune thyroid diseases or celiac disease) - main group, age 12.14±3.54 years) and 81 patients with only T1D (comparison group, age 11.57±3.34 years) were recruited. Groups were comparable in age (P</e...

Introduction: Prevalence of so-called diabetes prone to ketosis (DPK), has been increasing. The necessity of lifelong insulinotherapy is determined by Aβ classification of DPK.Design: Seven patients with atypical course of T2DM were studied. All patients had gradual development of hyperglycemia, obesity 1–2 stages, and acetonuria. Noone had acute weight loss. Stage 3 had positive GAD-AB, stage 4 – negative. Initially all patients were trea...

The use insulin pump therapy (IPT) (continuous subcutaneous insulin infusion (CSII)) has increased dramatically in youth with type 1 diabetes (T1D) in the past decade.Objective: Rate metabolic compensation of diabetes mellitus in children on IPT on the level HbA1c and self-control of glycaemia.Methods: The examination of 19 children aged 12.55±3.75 years (boys/girls=13/6), with T1D, observed in ‘2nd City Children’s H...

Hypothalamic amenorrhoea is a diagnosis of exclusion, frequent cause of which are medications or psychiatric disorders (bulimia/anorexia). Here we present a case, when its aetiology was gender identity disorder. A 18-year-old girl presented with absence of menses during last year. Menses began at the age of 14 and were regular till age of 16, when she moved to another city. She was seen by gynaecologist because of amenorrhea, and evaluation was performed: FSH 4.6 mU/ml (1.37&#...

Objective: To study feeding habits in children of different ages with alimentary obesity compared with normative values.Methods: We compared 3 days food diaries of 98 children with alimentary obesity observed in the Endocrinology Department of University Hospital (Minsk) with nutritional standards of healthy children recommended by Belarusian National Center for Hygiene, Epidemiology and Public Health – control (K). Patients were divided into three ...

Introduction: Graves’ disease (GD) is an autoimmune disorder of the thyroid gland, which is characterisied by a breakdown in immune tolerance. The lymphocytic infiltration of the thyroid leads to production of autioantibodies targeting thyroid stimulating hormone receptor (TSHR). The clinical course of GD varies among patients and it is difficult to predict the relapse risk after antithyroid therapy withdrawal. It is believed that GD occurs due to genetic suspectibility ...

Adrenal incidentaloma (AI) in patients with cancer poses diagnostic challenge for doctors. We present clinical case of generalised metastatic bone diseases and adrenal mass.Male 59 years old asked the second opinion about incidental adrenal mass, which was suspected for adrenal cancer by urologist. His medical anamnesis began in April of 2015 with severe generalised bone pain. The whole body MRI/CT detected multiple bone lesions, adrenal mass (57×45...